Patricia Arquette Opens Up About Brother's Transgender Operation

Patricia Arquette admits feeling a sense of "loss" when younger brother Alexis announced his plans to become a woman. The "Medium" star had questioned her open-mindedness when she doubted her brother's transgender plans.

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The 39-year-old actress says, "I had all the questions [for him] at first: 'Do you love yourself? Is it something that you want to change about the way you look?' I get concerned when anybody I love wants to do any change to the way they look - where's this coming from and why?"

She continues, "Accepting as I am, I didn't really understand and I can't say I really do understand it. But I did feel a sadness. Like, there's a loss. Am I going to lose my brother? I have memories of growing up - little faces we made, getting dressed up for Halloween."

"I always imagined myself to be a very open-minded person. So when I was feeling a level of judgment, I really had to think about myself."

Alexis, 38, had undergone transgender operation when he was 35. The whole experience was documented in the film, "Alexis Arquette: She's My Brother."